Porcine Primary Hepatocytes
Cryopreserved
Cytocine™ | Plateable - Catalog No.: CYTO-CYTO-PCP
Cytocine™ primary porcine hepatocytes (>5M viable cells / mL). Cryopreserved immediately upon isolation to ensure high post-thaw viability. Plateable with high attachment efficiency suitable for long-term (e.g., CYP450 induction) metabolic assays.
Cytocine™ | Suspension - Catalog No.: CYTO-PCS
Cytocine™ primary porcine hepatocytes (>5M viable cells / mL). Cryopreserved immediately upon isolation to ensure high post-thaw viability. Suspension-grade for short-term (2 – 4 h) metabolic assays.
Species: Porcine
Quantity: 1 vial, >5M viable cells
Source Organ: Liver
Cell Type: Hepatocyte
Storage and Shipping: Cryopreserved cells are transported in LN2 dry shippers. Upon receipt, immediately transfer vials to the vapor phase of liquid nitrogen until ready for use.
Product Overview
Cytocine™ cryopreserved primary porcine hepatocytes provide researchers with a valuable non-human model for various preclinical research applications, including drug development, toxicology, and liver disease studies. Their physiological and metabolic similarity to human hepatocytes give porcine hepatocytes an advantage over other non-human hepatocyte models such as rodent, canine and non-human primates. Cytocine™ hepatocytes provide a consistently available, high-quality and reliable option for researchers.
Key Features
- High Viability and Functionality: Retains critical metabolic functions post-thaw, including CYP450 enzyme activity, ammonia detoxification, and protein biosynthesis.
- Consistency: Large, predictable lots that undergo rigorous quality control testing, enabling reproducibility and consistent cell characteristics.
- Physiological Relevance: Shares key liver enzyme activities with human hepatocytes, making Cytocine™ hepatocytes an excellent model for drug metabolism, liver function, and toxicology studies.
- Cryopreservation: Advanced techniques ensure minimal cell damage, with high post-thaw viability and full metabolic functionality.
Applications
- Drug Metabolism (ADME) and Pharmacokinetics (DMPK)
- Drug-Drug Interaction (DDI) and Hepatotoxicity Testing
- Liver Disease Modeling and Therapeutic Research
- High-Throughput Screening for Drug Development
Why Choose Cytocine™ Porcine Hepatocytes?
- Controlled High-Health Source: Cytotheryx maintains pigs in a barrier environment with a carefully controlled production process, allowing for a comprehensive understanding of the pigs health history and status.
- Ethically Supported Model: Recognized by regulatory bodies as a complementary model to human hepatocytes and a viable alternative to canine and non-human primate (NHP) models.
- Xenotransplantation Potential: The increasing use of pigs in xenotransplantation research makes porcine hepatocytes a valuable preclinical model.
