The liver plays a vital role in the human body. Some of its many functions include detoxifying the blood, supporting digestion, and storing nutrients for the body’s use. The liver is also capable of a profound degree of regeneration. Combined with the fact that 80% of the liver is hepatocytes, this creates opportunities for liver cells to be used widely in research and clinical applications related to the many functions and capabilities of the liver and its cells. One of the biggest challenges facing research and development related to primary human hepatocytes, or liver cells, is the current supply. While available human hepatocytes do exist, the supply is dictated primarily by organ donations. The result is liver cells that are often inconsistent in quality and quantity when they are even available. With a more readily available, consistent, and high-quality source of primary human hepatocytes, the new gold standard of liver cells, Cytotheryx is able to provide a better solution for current uses of primary human hepatocytes while opening new doors for a wide variety of research and clinical applications.
The research applications of primary human hepatocytes are significant and varied. Hepatocytes are limited, costly, and inconsistent across lots of cells. With more dependability in the supply of primary human hepatocytes produced by Cytotheryx, researchers can strengthen existing applications, and consider new applications. Some applications include:
Our platform technology enables the use of hepatocytes for the treatment of liver diseases. As with the current research applications, the finite supply of available primary human hepatocytes limits clinical innovation. Cytotheryx’ platform technology enables us to propagate clinically safe, high-quality, consistent primary human hepatocytes at scale to meet a significant demand, which could allow the following clinical applications: